SAXS provides a wide range of information and is non-intrusive, giving it a distinct advantage over other structural characterization techniques. Investigation of biological materials in solution is therefore one of the strongest growing applications of SAXS.

A powerful technique

With proper sample preparation, SAXS on samples in solution can give information on a wide range of parameters including:

  • Aggregation
  • Molecular mass
  • Inter-particle interactions
  • Particle size distribution
  • Radius of gyration.
  • Protein conformation and oligomeric state
  • Protein stability
  • Characterizing the structure of polydisperse systems (mixture equilibrium)
  • Protein folding and unfolding
  • Low-resolution 3D shape reconstruction
  • Ligand interaction

Dedicated instrumentation increases output

SAXSLABs dedicated solution scattering instrument, the Bio-Nordic, is designed especially with bio-science research and users in mind. Using a temperature-controlled flow-through cell, robotic sample loading and easy to use software, we have removed many of the sample-handling challenges typically associated with solution SAXS. With a low learning curve and high degree of automation, the Bio-Nordic produces results quickly and efficiently while minimizing required user interaction.