SAXS provides a wide range of information and is non-intrusive, giving it a distinct advantage over other structural characterization techniques. Investigation of biological materials in solution is therefore one of the strongest growing applications of SAXS.
A powerful technique
With proper sample preparation, SAXS on samples in solution can give information on a wide range of parameters including:
- Molecular mass
- Inter-particle interactions
- Particle size distribution
- Radius of gyration.
- Protein conformation and oligomeric state
- Protein stability
- Characterizing the structure of polydisperse systems (mixture equilibrium)
- Protein folding and unfolding
- Low-resolution 3D shape reconstruction
- Ligand interaction
Dedicated instrumentation increases output
SAXSLABs dedicated solution scattering instrument, the Bio-Nordic, is designed especially with bio-science research and users in mind. Using a temperature-controlled flow-through cell, robotic sample loading and easy to use software, we have removed many of the sample-handling challenges typically associated with solution SAXS. With a low learning curve and high degree of automation, the Bio-Nordic produces results quickly and efficiently while minimizing required user interaction.